Adherens Junctions: from Molecular Mechanisms to Tissue by Tony J. C. Harris (auth.), Tony Harris (eds.)

By Tony J. C. Harris (auth.), Tony Harris (eds.)

Cell–cell adhesion is prime for the advance and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the simplest understood cell-cell adhesion complexes. during this quantity, a gaggle of the world over famous specialists studies AJ biology over quite a lot of association; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and total animal improvement. AJs have additionally been a vital part of animal evolution, and play principal roles in melanoma improvement, pathogen an infection and different ailments. This booklet addresses significant questions encompassing AJ biology.
• How did AJs evolve?
• How do cadherins and catenins engage to collect AJs and mediate adhesion?
• How do AJs interface with different mobile equipment to couple adhesion with the full phone?
• How do AJs impact mobilephone behaviour and multicellular improvement?
• How can irregular AJ job result in disease?

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The presence of Trp as the second residue on the N terminus is critical for this process and is attained by proteolytic cleavage of the cadherin prodomain (discussed later) (Häussinger et al. 2004). The EC1 domains of type II-subfamily of cadherins, such as cadherin-8, cadherin-11 and VE-cadherin, have been also shown to engage in strand-swap dimerization similar to the ones observed for classical cadherins, but their interactions involve two N-terminal Trp residues (Trp2 and Trp4) being inserted into a larger hydrophobic pocket (Brasch et al.

Oda specific to vinculins have only been found within the metazoans. The ancestral form for this family appears to be α-catenin-like. Ddα-catenin binds to Aardvark and mouse β-catenin in vitro and localizes to regions of cell–cell contact in an Aardvark-dependent manner in vivo (Dickinson et al. 2011). Purified Ddα-catenin, unlike mammalian αE-catenin, does not form homodimers but it is capable of bundling F-actin. Both Ddα-catenin and Aardvark are required to organize and polarize the tip epithelium.

021 Eisenmann DM (2005) Wnt signaling. WormBook 25:1–17 Elledge HM, Kazmierczak P, Clark P, Joseph JS, Kolatkar A, Kuhn P, Müller U (2010) Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members. Proc Natl Acad Sci U S A 107:10708–10712. 1006284107 Ereskovsky AV, Borchiellini C, Gazave E, Ivanisevic J, Lapébie P, Perez T, Renard E, Vacelet J (2009) The Homoscleromorph sponge Oscarella lobularis, a promising sponge model in evolutionary and developmental biology: model sponge Oscarella lobularis.

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